Table 3.
The diagnostic value of various combinations in distinguishing between benign and malignant neoplasms
| Items | Youden index | Sensitivity | Specificity | Accuracy | PPV | NPV |
|---|---|---|---|---|---|---|
| Shape | 0.551 | 95.7% (45/47) | 59.4% (60/101) | 70.9% (105/148) | 52.3% (45/86) | 96.8% (60/62) |
| Capsule | 0.68 | 80.9% (38/47) | 87.1% (88/101) | 85.1% (126/148) | 74.5% (38/51) | 90.7% (88/97) |
| Mean ADC value | 0.43 | 91.5% (43/47) | 51.5% (52/101) | 64.2% (95/148) | 46.7% (43/92) | 92.9% (52/56) |
| TIC | 0.629 | 78.7% (37/47) | 84.2% (85/101) | 82.4% (122/148) | 69.8% (37/53) | 89.5% (85/95) |
| Shape + capsule | 0.624 | 72.3% (34/47) | 90.1% (91/101) | 86.5% (128/148) | 78.7% (37/47) | 90.1% (91/101) |
| Shape + ADC | 0.773 | 87.2% (41/47) | 90.1% (91/101) | 89.2% (132/148) | 80.4% (41/51) | 93.8% (91/97) |
| Shape + TIC | 0.728 | 78.7% (37/47) | 94.1% (95/101) | 89.2% (132/148) | 86.0% (37/43) | 90.5% (95/152) |
| Capsule + ADC | 0.686 | 74.5% (35/47) | 94.1% (95/101) | 87.8% (130/148) | 85.4% (35/41) | 94.1% (95/101) |
| Capsule + TIC | 0.682 | 70.2% (33/47) | 98.0% (99/101) | 89.2% (132/148) | 97.1% (34/35) | 87.6% (99/113) |
| ADC + TIC | 0.695 | 74.5% (35/47) | 95.0% (96/101) | 88.5% (131/148) | 87.5% (35/40) | 88.9% (96/108) |
| Shape + capsule + ADC | 0.773 | 87.2% (41/47) | 90.1% (91/101) | 89.2% (132/148) | 80.4% (41/51) | 93.8% (91/97) |
| Shape + capsule + TIC | 0.728 | 78.7% (37/47) | 94.1% (95/101) | 89.2% (132/148) | 86.0% (37/43) | 90.5% (95/105) |
| Shape + ADC + TIC | 0.773 | 87.2% (41/47) | 90.1% (91/101) | 89.2% (132/148) | 80.4% (41/51) | 93.8% (91/97) |
| Capsule + ADC + TIC | 0.743 | 87.2% (41/47) | 87.1% (88/101) | 87.2% (129/148) | 75.9% (41/54) | 93.6% (88/94) |
| Combination of all items | 0.792 | 85.1% (40/47) | 94.1% (95/101) | 91 2% (135/148) | 87.0% (40/46) | 93.1% (95/102) |
ADC, apparent diffusion coefficient; NPV, negative-predictive value; PPV, positive-predictive value; TIC, time–intensity curve.