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. 2017 Apr 18;31(9):1121–1136. doi: 10.1177/0269881117699612

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 1. — Schematic of the 5-HT presynaptic terminal processes and signal transduction pathways. Abbreviations as defined in main text. Only metabotropic 5-HT receptors are shown. Compared with Table 1.

5-HT: 5-hydroxytryptamine; SERT: serotonin reuptake transporter; Gα_i/Gα_o, Gα_s, Gα_q: isoforms of the α subunits of G protein-coupled receptors; AC: adenylyl cyclases; cAMP: cyclic adenosine monophosphate; EPAC: exchange proteins activated by cAMP; PKA: protein kinase A; CREB: cAMP response element-binding protein; Raf: rapidly accelerated fibrosarcoma kinase; ERK: extracellular signal regulated kinase; PLC: phospholipase C; IP3: inositol 1,4,5-trisphosphate; DAG: diacylglycerol; PIP2: phospholipid phosphatidylinositol 4,5-bisphosphate; ER: endoplasmic reticulum; PKC: protein kinase C.