Table 1. Proteins with a known role in HIV reactivation, up- or downregulated as the result of SAHA treatment.

An implied effect of SAHA treatment on HIV transcription, based on the function of a given protein and the direction of its modulation by SAHA, is indicated in the rightmost column.

Description	Protein (gene symbol)	Gene name	Reference(s)	Transcript modulated?	Effect on HIV transcription
		Proteins that act to activate HIV transcription
Upregulated by SAHA	HSPA1A	heat shock 70kDa protein 1A	O'Keeffe et al., 2000	no/yes*	+
	KDM1A	lysine (K)-specific demethylase 1A	Sakane et al., 2011	No	+
Downregulated by SAHA	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	Bassuk et al., 1997; Posada et al., 2000; Sieweke et al., 1998; Yang et al., 2009	No	−
	LEF1	lymphoid enhancer-binding factor 1	Sheridan et al., 1995	No	−
	IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	Mercurio et al., 1997; Nabel and Baltimore, 1987	No	−
		Proteins that act to inhibit HIV transcription
Upregulated by SAHA	HMGA1	high mobility group AT-hook 1	Eilebrecht et al., 2014; Eilebrecht et al., 2013	Yes	−
	ASF1A	anti-silencing function 1A histone chaperone	Gallastegui et al., 2011	Yes	−
	BRD2	bromodomain containing 2	Boehm et al., 2013	No	−
	BRDT	bromodomain, testis-specific	Bisgrove et al., 2007	No	−
Downregulated by SAHA	AES	amino-terminal enhancer of split	Tetsuka et al., 2000	Yes	+
	ARID1B (BAF250)	AT rich interactive domain 1B (SWI1-like)	Mahmoudi, 2012; Rafati et al., 2011	No	+

Plus sign, possible positive effect on HIV transcription, e.g. resulting from upregulation of an activator or downregulation of a repressor. Minus sign, possible negative effect on HIV transcription, e.g. resulting from downregulation of an activator or upregulation of a repressor.

Asterisk indicates that for heat shock protein 70, one gene (HSPA1A) was modulated by SAHA at the protein level only, while another gene (HSPA2) was modulated only at the transcript level.