Table 3.
Mean biochemical indices as compared to controls.
| Duration of Exposure | Sub-Group | AST (μ/L) | ALT (μ/L) | Urea (mg/dL) | Creatinine (mg/dL) |
|---|---|---|---|---|---|
| Day 1 | Control A | 29 ± 2.65 | 31.67 ± 4.51 | 20.28 ± 1.89 | 1.17 ± 0.09 |
| Test A | 30.33 ± 8.74 a+ | 37.67 ± 0.58 a+ | 24.4 ± 0.81 *a+ | 1.51 ± 0.09 * | |
| Day 7 | Control B | 30.67 ± 7.37 | 40.33 ± 6.66 | 23 ± 1.39 | 1.19 ± 0.17 |
| Test B | 51.67 ± 1.53 *b+ | 72 ± 5.29 * | 25.55 ± 2.37 | 1.37 ± 0.22 | |
| Day 14 | Control C | 32.33 ± 3.21 | 35 ± 1.73 | 23.83 ± 2.34 | 1.23 ± 0.03 |
| Test C | 59.33 ± 4.04 *c | 63 ± 3.0 * | 29.98 ± 5.5 | 1.25 ± 0.05 | |
| Day 21 | Control D | 36.33 ± 3.51 | 37.33 ± 1.15 | 22.27 ± 1.45 | 1.17 ± 0.07 |
| Test D | 76.33 ± 3.79 * | 64.67 ± 4.04 * | 24.55 ± 1.45 + | 1.46 ± 0.19 | |
| Day28 | Control E | 37 ± 6.25 | 32 ± 1.0 | 22.85 ± 1.28 | 1.15 ± 0.06 |
| Test E | 67.33 ± 3.06 * | 65.33 ± 5.03 * | 34.96 ± 3.46 * | 1.48 ± 0.17 * | |
| Day 35 (seven days withdrawal) | Control F | 32.67 ± 4.51 | 35.67 ± 3.21 | 22.01 ± 1.39 | 1.2 ± 0.05 |
| Test F | 66 ± 3.61 * | 63 ± 1.0 * | 35.66 ± 6.12 * | 1.56 ± 0.1 * |
* indicates significantly different compared to control (p < 0.05); within the test group + significantly different from day 35; AST: ‘a’ significantly different compared with day 7, 14, 21 and 28, ‘b’ significantly different compared to day 21 and 28, ‘c’ significantly different compared with day 21; ALT: ‘a’ significantly different compared to day 7, 14, 21 and 28; Urea: ‘a’ significantly different compared with day 28.