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. 2017 Sep 20;6:e27872. doi: 10.7554/eLife.27872

Figure 5. Loss of translin prevents elevation of ACVR1C protein levels 30 min following training in the object location memory task.

Figure 5.

Training induced an increase in translin levels in hippocampal synaptosomes (t-test, p=0.01), while the loss of translin prevented a training-induced upregulation of synaptosomal ACVR1C levels in the hippocampus (two-way ANOVA: genotype, F(1,16) = 5.2, p=0.03; training, F(1,16) = 6.8, p=0.02; genotype X training, F(1,16) = 5.7, p=0.03; Dunnett’s post hoc test, WThomecage vs. WTtraining: p=0.01, WThomecage vs. KOtraining: p=0.9). However, synaptosomal vang-like 2 (VANGL2) levels were unaffected by either genotype or training (two-way ANOVA: genotype, F(1,16) = 0.06, p=0.8; training, F(1,16) = 0.3, p=0.6; genotype X training, F(1,16) = 0.06, p=0.8). Syn: synaptophysin. HC: homecage. * indicates p<0.05. n, number of mice. Data are represented as mean ±SEM.