Table 3. Multivariable predictors for time to recurrent blood-stage infection with Plasmodium species by qPCR.
Variable | P. vivax | P. falciparum | P. malariae | P. ovale | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AHR* | CI95 | p-value | AHR* | CI95 | p-value | AHR* | CI95 | p-value | AHR* | CI95 | p-value | |
PQ treatment | 0.18 | 0.13–0.25 | <0.001 | 0.73 | 0.52–1.02 | 0.064 | 0.51 | 0.22–1.19 | 0.121 | 0.31 | 0.12–0.75 | 0.010 |
Age | 0.95 | 0.87–1.04 | 0.247 | 1.05 | 0.94–1.17 | 0.361 | 0.98 | 0.75–1.29 | 0.905 | 0.96 | 0.74–1.26 | 0.793 |
LLIN use at enrolment | 0.62 | 0.39–0.98 | 0.043 | 0.84 | 0.49–1.44 | 0.531 | 1.33 | 0.33–6.09 | 0.715 | 0.95 | 0.26–3.43 | 0.936 |
Hb at enrolment (g/dl) | 0.88 | 0.80–0.98 | 0.019 | 0.90 | 0.80–1.02 | 0.099 | 0.83 | 0.61–1.12 | 0.224 | 0.92 | 0.66–1.28 | 0.634 |
Village | ||||||||||||
Albinama (ref) | 1 | 1 | 1 | 1 | ||||||||
Amahup | 0.45 | 0.29–0.71 | 0.001 | 0.58 | 0.31–1.11 | 0.101 | 0.34 | 0.07–1.79 | 0.205 | 2.83 | 0.29–27.48 | 0.370 |
Balanga | 2.15 | 1.40–3.31 | <0.001 | 1.81 | 0.99–3.30 | 0.054 | 0.92 | 0.24–3.60 | 0.910 | 7.74 | 0.85–70.45 | 0.070 |
Balif | 1.00 | 0.66–1.54 | 0.983 | 0.60 | 0.30–1.19 | 0.145 | 0.24 | 0.03–2.07 | 0.193 | 4.60 | 0.51–41.41 | 0.173 |
Bolumita | 3.34 | 2.09–5.33 | <0.001 | 4.73 | 2.69–8.30 | <0.001 | 1.21 | 0.34–4.31 | 0.770 | 19.43 | 2.19–172.37 | 0.008 |
Numangu | 0.83 | 0.44–1.59 | 0.583 | 2.29 | 1.17–4.50 | 0.015 | 0.82 | 0.15–4.53 | 0.823 | 3.17 | 0.19–52.41 | 0.420 |
Infection status at enrolment (by qPCR) | ||||||||||||
Uninfected (ref) | 1 | 1 | 1 | 1 | ||||||||
P. vivax | 1.27 | 0.91–1.78 | 0.165 | 1.37 | 0.86–2.20 | 0.186 | 0.92 | 0.20–4.18 | 0.913 | 2.17 | 0.68–6.97 | 0.192 |
P. falciparum | 1.36 | 0.84–2.19 | 0.205 | 1.56 | 0.86–2.82 | 0.145 | 3.54 | 0.85–14.72 | 0.083 | 1.25 | 0.26–5.90 | 0.779 |
P. malariae | 0.83 | 0.38–1.85 | 0.655 | 0.99 | 0.38–2.56 | 0.977 | 6.35 | 1.31–30.81 | 0.022 | 1.58 | 0.17–14.30 | 0.676 |
Mixed P.f. or P.v.† | 1.74 | 1.14–2.65 | 0.010 | 2.08 | 1.25–3.48 | 0.005 | 3.37 | 0.88–12.90 | 0.076 | 2.03 | 0.55–7.53 | 0.287 |
* AHRs were modeled using Cox proportional hazard regression.
† Mixed infection including P. falciparum or P. vivax infection in conjunction with one or more other Plasmodium spp.
PQ: Primaquine; LLIN: long-lasting insecticide-treated net; Hb: haemoglobin.