Table 3. Histological severity of lean NAFLD compared to obese NAFLD.
| StudyRef | Lean/Obese | NAS (0–8) | Fibrosis | NASH NAS > 4 | Advanced Fibrosis > F2 | ||||
| Lean | Obese | Lean | Obese | Lean | Obese | Lean | Obese | ||
| Leung et al.4 | 72/235 | 3.3 ± 1.3 | 3.8 ± 1.2* | 1.3 ± 1.5 | 1.7 ± 1.4* | 43.5% | 51.9% | 26.1% | 27.7% |
| Alam et al.6 | 56/164 | 4.4 ± 1.4 | 4.1 ± 1.1 | 1.2 ± .8 | 1.1 ± 0.8 | 53.5% | 46.9% | 19.6% | 18.9% |
| Kumar et al.5 | 18/73 | 3.3 ± 1.5 | 4.1 ± 1.4 | 01 (0–04) | 02 (0–04)* | 28% | 38% | 5.6% | 27% |
| Akyuz et al.79 | 37/446 | 5 (2–7) | 5 (4–6) | 0 (0–1) | 1 (0–2)* | – | – | 0 | 0 |
| Honda et al.8 | 134/406 | 3.5 ± 1.6 | 4.2 ± 1.5* | 1.6 ± 1.1 | 1.7 ± 1.0 | – | – | – | |
*
Significantly different between lean and obese.
Abbreviations: NAS, NAFLD activity score; NASH, non-alcoholic steatohepatitis.