Table 3. Differences in cerebellar DTI scalars between 8 neonates with severe HIE and hypothermia therapy and 12 neonatal controls.

DTI scalars	Anatomical region	HIE, mean (95% CI)	Controls, mean (95% CI)	p value
FA	SCP	0.347 (0.319–0.374)	0.328 (0.306–0.350)	0.28
	MCP	0.294 (0.259–0.328)	0.380 (0.352–0.408)	<0.001
	ICP	0.277 (0.237–0.316)	0.289 (0.258–0.321)	0.60
	Dentate nuclei	0.140 (0.118–0.161)	0.156 (0.138–0.173)	0.24
MD, ×10−3 mm/s2	SCP	0.920 (0.884–0.956)	1.007 (0.977–1.036)	0.001
	MCP	1.106 (1.061–1.151)	1.090 (1.053–1.127)	0.57
	ICP	0.988 (0.944–1.033)	0.981 (0.945–1.017)	0.78
	Dentate nuclei	1.184 (1.083–1.285)	1.199 (1.117–1.281)	0.82

Statistically significant differences are in bold type. DTI scalars have been adjusted for gestational age and age at the time of MRI by linear regression; least-squares means are presented. DTI, diffusion tensor imaging; FA, fractional anisotropy; HIE, hypoxic-ischemic encephalopathy; ICP, inferior cerebellar peduncle; MCP, middle cerebellar peduncle; MD, mean diffusivity; SCP, superior cerebellar peduncle.