Effect of alginate microspheres (alginate microbeads and microcapsules) on coagulation (PTF1.2) and complement (TCC) responses in the human whole blood model. A) Time-dependent effect on PTF1.2 (mean±SEM, N=4 donors), B) PTF1.2 at 240 min (N=11–14 donors), C) Time effect on TCC (mean±SEM, N=4 donors), D) TCC after 240 min (N=12–14). The data in B and D are given as box whisker plots with median, 25th and 75th percentiles and min/max values, and the level of significance shown as * P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001.