Table 1.
sample characteristics
| Characteristics | Central Pathologist Assigned Rejection | Total (N=400) | |
|---|---|---|---|
|
| |||
| Yes (N=43) | No (N=357) | ||
| Total participants | 43 (100.0%) | 357 (100.0%) | 400 (100.0%) |
| Primary diagnosis | |||
| Biliary Atresia | 18 (41.9%) | 175 (49.0%) | 193 (48.3%) |
| Other Cholestatic | 5 (11.6%) | 30 (8.4%) | 35 (8.8%) |
| Acute Liver Failure | 7 (16.3%) | 34 (9.5%) | 41 (10.3%) |
| Metabolic | 7 (16.3%) | 53 (14.8%) | 60 (15.0%) |
| Tumor | 3 (7.0%) | 31 (8.7%) | 34 (8.5%) |
| Autoimmune Hepatitis | 1 (2.3%) | 2 (0.6%) | 3 (0.8%) |
| Other | 2 (4.7%) | 32 (9.0%) | 34 (8.5%) |
| Age at transplant | |||
| < 1 year | 13 (30.2%) | 156 (43.7%) | 169 (42.3%) |
| 1–4 years | 15 (34.9%) | 130 (36.4%) | 145 (36.3%) |
| 5–12 years | 11 (25.6%) | 67 (18.8%) | 78 (19.5%) |
| 13–17 years | 4 (9.3%) | 4 (1.1%) | 8 (2.0%) |
| Age at baseline (years) | |||
| N | 43 | 357 | 400 |
| Mean (SD) | 10.7 (5.0) | 9.5 (4.4) | 9.6 (4.5) |
| Median (Min, Max) | 12.3 (1.9, 17.8) | 9.5 (1.4, 18.0) | 9.7 (1.4, 18.0) |
| Gender | |||
| Male | 12 (27.9%) | 177 (49.6%) | 189 (47.3%) |
| Female | 31 (72.1%) | 180 (50.4%) | 211 (52.8%) |
| Race | |||
| American Indian or Alaska Native | 0 | 1 (0.3%) | 1 (0.3%) |
| Asian | 4 (9.3%) | 21 (5.9%) | 25 (6.3%) |
| Black or African American | 11 (25.6%) | 45 (12.6%) | 56 (14.0%) |
| Native Hawaiian or Pacific Islander | 1 (2.3%) | 1 (0.3%) | 2 (0.5%) |
| White or Caucasian | 22 (51.2%) | 246 (68.9%) | 268 (67.0%) |
| Other | 1 (2.3%) | 24 (6.7%) | 25 (6.3%) |
| More than one race | 1 (2.3%) | 2 (0.6%) | 3 (0.8%) |
| Not reported | 3 (7.0%) | 17 (4.8%) | 20 (5.0%) |
| Donor organ type | |||
| Deceased whole liver | 22 (51.2%) | 159 (44.5%) | 181 (45.3%) |
| Deceased technical variant (reduced and split) | 11 (25.6%) | 117 (32.8%) | 128 (32.0%) |
| Living | 10 (23.3%) | 81 (22.7%) | 91 (22.8%) |
| Surgical procedure | |||
| Orthotopic | 43 (100.0%) | 355 (99.4%) | 398 (99.5%) |
| Heterotopic | 0 | 2 (0.6%) | 2 (0.5%) |
| Primary insurance | |||
| Medicaid or equivalent and/or state funded children’s services | 21 (48.8%) | 135 (37.8%) | 156 (39.0%) |
| HMO/managed care | 12 (27.9%) | 89 (24.9%) | 101 (25.3%) |
| Traditional private insurance | 8 (18.6%) | 86 (24.1%) | 94 (23.5%) |
| Champus (military) | 0 | 4 (1.1%) | 4 (1.0%) |
| None: self pay | 0 | 28 (7.8%) | 28 (7.0%) |
| None: no funding | 1 (2.3%) | 3 (0.8%) | 4 (1.0%) |
| Other | 1 (2.3%) | 12 (3.4%) | 13 (3.3%) |
| Primary caregiver | |||
| Mother | 40 (93.0%) | 311 (87.1%) | 351 (87.8%) |
| Father | 3 (7.0%) | 37 (10.4%) | 40 (10.0%) |
| Guardian | 0 | 5 (1.4%) | 5 (1.3%) |
| Other | 0 | 4 (1.1%) | 4 (1.0%) |
| Primary caregiver’s marital status | |||
| Missing | 0 | 3 (0.8%) | 3 (0.8%) |
| Single-parent household | 10 (23.3%) | 70 (19.6%) | 80 (20.0%) |
| Two-parent household | 33 (76.7%) | 284 (79.6%) | 317 (79.3%) |
| Primary caregiver’s highest level of education | |||
| Missing | 0 | 22 (6.2%) | 22 (5.5%) |
| Some high school or less | 5 (11.6%) | 38 (10.6%) | 43 (10.8%) |
| High school degree/GED | 16 (37.2%) | 81 (22.7%) | 97 (24.3%) |
| Vocational school or some college | 7 (16.3%) | 70 (19.6%) | 77 (19.3%) |
| College degree | 12 (27.9%) | 103 (28.9%) | 115 (28.8%) |
| Professional or graduate degree | 3 (7.0%) | 43 (12.0%) | 46 (11.5%) |
| Time since transplant at enrollment into MALT (years) | |||
| N | 43 | 357 | 400 |
| Mean (SD) | 5.7 (4.7) | 6.9 (4.3) | 6.8 (4.4) |
| Median (Min, Max) | 3.4 (1.0, 16.7) | 6.0 (1.0, 17.4) | 5.9 (1.0, 17.4) |