TABLE 4.
Final Multivariate Logistic Regression Model Assessing Effect of MLVI > 2.5 on Central Pathologist Confirmed Rejection1.
| Factor | Reference Group | Comparison Group | Odds Ratio | 95% CI | Pairwise P Value | Overall P Value |
|---|---|---|---|---|---|---|
| MLVI > 2.5 | No | Yes | 2.54 | (1.17, 5.53) | 0.02 | 0.02 |
| Age at baseline | 1–12 years | 13–17 years | 2.66 | (1.30, 5.46) | 0.007 | 0.007 |
| Center | Center A | Center B | 3.91 | (1.35, 11.28) | 0.012 | 0.02 |
| Center C | 2.41 | (0.73, 7.96) | 0.15 | |||
| Center D | 1.03 | (0.29, 3.66) | 0.96 | |||
| Center E | 0.94 | (0.27, 3.35) | 0.93 |
1
The baseline factors evaluated included primary diagnosis, age at baseline (enrollment in MALT), race, time from transplant to MALT enrollment, primary insurance (state/federal funded vs traditional private insurance), and center. The backward elimination method was used to develop the final multivariate model.