Figure 1.

Single- and double-dose effects measured by relative risks (RRs) for minor alleles of the 15 fetal single-nucleotide polymorphisms that had significant effects for 1 of the case categories: isolated cleft lip only (CLO), isolated cleft lip and palate (CLP), and isolated cleft palate only (CPO). Black squares represent single-dose effects; red squares represent double-dose effects; and lines are 95% confidence intervals. We include only rs3758249 in FOXE1 in this figure because haplotype analysis indicated that the effect of rs10984103 is explained by the minor allele of the first single-nucleotide polymorphism (Appendix Fig. 2).