Table 1.

Fetal SNP Effects on Isolated Cleft Lip Only.

Genes/Locus	SNP	RRa	95% CI	P Valueb	P Value–Sitec
PAX7	rs742071	1.52	1.31 to 1.75	3.74E-08	0.90
ABCA4-ARHGAP29	rs560426	1.10	0.95 to 1.27	0.20	0.52
IRF6	rs2235371	0.80	0.45 to 1.43	0.45	0.95
IRF6	rs642961	1.60	1.36 to 1.87	1.42E-08	0.69
THADA	rs7590268	1.16	0.98 to 1.36	0.08	0.83
MSX1	rs3111689	1.15	0.98 to 1.36	0.09	0.11
8q21.3	rs12543318	1.51	1.31 to 1.75	4.46E-08	0.87
8q24	rs987525	1.93	1.65 to 2.25	5.88E-16	0.65
FOXE1	rs7864322	0.86	0.74 to 1.01	0.07	0.78
FOXE1	rs10818094	0.99	0.84 to 1.18	0.95	0.88
FOXE1	rs1443433	0.91	0.74 to 1.12	0.40	0.75
FOXE1	rs74934500	0.73	0.45 to 1.18	0.19	0.97
FOXE1	rs3758249	0.80	0.69 to 0.93	0.004	0.95
FOXE1	rs10984103	0.82	0.70 to 0.96	0.01	0.89
KIAA1598-VAX1	rs7078160	1.32	1.11 to 1.57	0.002	0.16
KIAA1598-VAX1	rs4752028	1.34	1.13 to 1.60	8.34E-04	0.20
FGFR2	rs4752566	0.90	0.78 to 1.05	0.18	0.64
FGFR2	rs2912760	1.12	0.96 to 1.32	0.16	0.02
FGFR2	rs3135761	1.10	0.92 to 1.32	0.30	0.43
FGFR2	rs2912771	0.83	0.70 to 0.99	0.04	0.04
FGFR2	rs2981428	1.09	0.94 to 1.26	0.26	0.77
FGFR2	rs3750817	1.00	0.86 to 1.16	1.00	0.50
SPRY2	rs8001641	0.82	0.71 to 0.95	0.008	0.81
TPM1	rs1873147	1.31	1.13 to 1.53	5.82E-04	0.31
CRISPLD2	rs1546124	1.00	0.86 to 1.17	0.96	0.57
NTN1	rs4791331	1.16	0.95 to 1.42	0.14	0.20
NTN1	rs8069536	1.18	1.02 to 1.36	0.03	0.49
NOG1	rs227731	1.36	1.18 to 1.58	2.79E-05	0.45
MAFB	rs13041247	0.71	0.61 to 0.82	9.85E-06	0.81
MYH9	rs3752462	1.10	0.94 to 1.28	0.24	0.11
MYH9	rs1002246	1.12	0.96 to 1.30	0.14	0.99

95% CI, 95% confidence interval; RR, relative risk; SNP, single-nucleotide polymorphism.

^aRR for heterozygotes. RR for homozygotes is estimated as the square.

^bEffect of child’s allele in multiplicative model. Significant with Bonferroni adjustment if P < 0.0016.

^cTest of heterogeneity of estimates across sites.