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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Aug 30;27(19):4544–4547. doi: 10.1016/j.bmcl.2017.08.057

Table 1.

MIC99 for ester-protected ethambutol derivatives.

Compound MIC99 (μg/mL)* MIC99 + PLE (μg/mL) MIC99 + PLE + PMSF (μg/mL)
1 0.098 0.098 0.098
3a 0.78 0.78 0.78
3b 3.1 0.39 6.2
3c 6.3 0.098 1.6
3d 6.3 0.78 6.3
3e 13 0.78 25
3f 6.3 0.39 6.3
3g 6.3 0.20 0.39
3h 1.6 0.20 0.78
*

MIC99 was measured against M. smegmatis. The highest concentration sample in the MIC99 dilutions was preincubated with PMSF (1mM), PLE (0.1 mg/mL), or the combination of PLE and PMSF for 1 hour at RT before dilution. The A600 of the growth plates were measured after 72 h of culture growth at 37 °C and 225 rpm.