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. Author manuscript; available in PMC: 2018 Sep 20.
Published in final edited form as: Metallomics. 2017 Sep 20;9(9):1260–1270. doi: 10.1039/c7mt00104e

Table 1.

Effects of TD-1 treatment on oxygen binding characteristics and autoxidation rates of hemoglobin and red blood cells

Sample P50 of RBCs (mmHg) Hill Coefficient (n) Rate constant of autooxidation of Hb (h−1)
HbS without TD-1     35.30     1.75     0.039 ± 0.01
HbS with TD-1     15.36     1.58     0.045 ± 0.02
HbA without TD-1     25.22     1.98     0.035 ± 0.02
HbA with TD-1     11.68     2.07     0.05 ± 0.01

Whole blood samples from a sickle cell patient and ethnically matched control (approximately 20% Hct) were incubated with TD-1 (2 mM) for 15 min in Hemox buffer, pH 7.4. The rate constant of autoxidation for HbS and HbA (n=3) were determined in 50mM phosphate buffer, pH 7.4.