Table 2. Potential HI-related risk factors for PVL.
| Risk factors | Numbers of studies | Pooled ORs (95% CI) | P-value* |
|---|---|---|---|
| Prepartum/intrapartum risk factors | |||
| Preeclampsia/eclampsia | 10 | 0.68 (0.49, 0.93) | 0.01 |
| Abruption placenta | 7 | 1.19 (0.76, 1.87) | 0.44 |
| Oligohydramnios | 4 | 1,55 (1.05, 2.30) | 0.03 |
| Intrauterine growth restriction | 5 | 0.71 (0.33, 1.57) | 0.40 |
| Vaginal bleeding | 4 | 1.30 (0.90, 1.88) | 0.17 |
| Breech delivery | 3 | 0.87 (0.44, 1.74) | 0.70 |
| Neonatal risk factors | |||
| Acidemia | 6 | 1.87 (1.18, 2.97) | <0.01 |
| Low Apgar score | 7 | 2.69 (1.13, 6.41)a | 0.03 |
| 1.89 (1.39, 2.56)b | <0.01 | ||
| Asphyxia | 1 | - | - |
| Apnea | 2 | 1.76 (1.07, 2.90) | 0.03 |
| Respiratory distress syndrome | 6 | 1.46 (1.04, 2.03) | 0.03 |
| Seizures | 6 | 4.60 (2.84, 7.46) | <0.01 |
| Patent ductus arteriosus requiring surgical treatment | 4 | 1.22 (0.72, 2.05) | 0.46 |
| Hypocarbia | 1 | - | - |
*: Significant positive result (P <0.05)
a: 1-minute Apgar score <7
b: 5-minute Apgar score <7
Abbreviations: OR, odds ratio; CI, confidence interval