. 2017 Sep 20;12(9):e0184766. doi: 10.1371/journal.pone.0184766

Table 2. Differences at last measurement between HIV patients who had never received TDF-containing ART(ART_{TDF free}), those who continuously took a TDF-containing ART (ART_TDF), and those who switched to TDF free (ART_switched) at Chreso Ministries in Lusaka, Zambia 2011–2013.

		ART_{TDF free} (N = 189)				ART_TDF (N = 856)				ART_switched (N = 73)
variable		N	%	mean	sd	N	%	mean	sd	N	%	mean	sd	p-value
Sex	women	124	66			533	62			51	70			0.34^a
duration of HIV infection [days]		189	100	2055	803	856	100	1511	789	73	100	1776	844	<0.001^b
duration of ART intake [days]		189	100	1918	713	856	100	1357	791	73	100	1635	782	<0.001^b
Age [years]		189	100	42.2	9.1	856	100	41.6	8.9	73	100	42.9	11.3	0.42^b
BMI [kg/m²]	men	48	74	23.3	4.2	271	84	23.1	4.2	18	82	24.4	4.3	0.45^b
	women	104	84	25.3	4.9	447	81	25.5	5.1	40	78	23.6	3.9	0.06^b
mean arterial pressure [mmHg]		149	79	100.0	15.7	711	83	95.5	16.2	60	82	98.1	18.7	0.006^b
systolic blood pressure [mmHg]		149	79	134.3	22.1	711	83	127.1	22.1	60	82	131.9	26.1	<0.001^b
CD4 [ml^-1]		147	78	455	251	689	80	407	203	41	56	404	247	0.05^b
haemoglobin [g/dl]		137	72	13.0	1.8	609	71	12.7	2.0	42	58	12.0	2.1	0.02^b
AST [U/l]		161	85	28.6	15.2	779	91	31.0	18.1	53	73	25.8	9.6	0.04^b
ALT [U/l]		173	92	28.0	25.5	821	96	28.9	18.7	57	78	24.7	14.8	0.28^b
creatinine [mg/dl]		189	100	0.8	0.3	856	100	0.8	0.3	73	100	1.1	0.6	<0.001^b
CKD-EPI eGFR [ml/min/1.73m²]		189	100	100.8	21.4	856	100	101.1	21.4	73	100	81.5	30.4	<0.001^b
eGFR category	1, 2	178	94			826	96			52	71			<0.001^a
	3a-5	11	6			30	4			21	29
Anaemia^c	yes	44	32			222	36			20	48			0.19^a
	no	93	68			387	64			22	52
	missing	52	28			247	29			31	42
liver encymes	yes	4	3			16	2			1	2			0.94^a
>2•ULN^d	no	157	97			760	98			52	98
	missing	28	15			80	9			20	27
liver encymes	yes	1	1			0	0			0	0			0.08^a
>5•ULN^e	no	159	99			775	100			53	100
	missing	29	15			81	9			20	27
systolic blood	<120 mmHg	40	27			284	40			22	37			0.004^a
pressure	120–139 mmHg	56	38			250	35			16	27
	> = 140 mmHg	53	36			177	25			22	38
	missing	40	21			145	17			13	18

^a χ2-test

^b ANOVA, two-sided

^c Anaemia was defined as Hgb below 13 [g/dl] for men, and below 12 [g/dl] for women.

^d Liver disease was defined if at least ALT or AST were twice the upper limit of normal (ULN) of 50 [U/l] for men and 35 [U/l] for women.

^e Presence of severe liver disease was assumed if at least ALT or AST were five times higher than the ULN.

Table 2. Differences at last measurement between HIV patients who had never received TDF-containing ART(ARTTDF free), those who continuously took a TDF-containing ART (ARTTDF), and those who switched to TDF free (ARTswitched) at Chreso Ministries in Lusaka, Zambia 2011–2013.