Figure 4.

Comparison of the effects induced by the different gp41 MPER-TMD-derived peptides on the packing and lateral organization of VL membranes. (A) GP values were determined for VL GUVs that contained peptide (peptide/lipid 1:500). (B) Given here is the nanoscopic structure, as determined by AFM analyses of the peptide-containing VL monolayers (top) and height difference between demixed domains and the surrounding lipid surface (bottom). Monolayers were supplemented with peptide to a peptide/lipid 1:100. Conditions otherwise as in the previous Figs. 2 and 3. Mann-Whitney test: ^∗∗∗p < 0.001, ^∗∗p < 0.01, ^∗p < 0.05, not significant (n.s.) ≥ 0.05. To see this figure in color, go online.