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. 2017 Sep 6;8:196–207. doi: 10.1016/j.dadm.2017.07.006

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Class-specific networks visualized with the Fruchterman-Reingold [33] algorithm. The upper left panel contains the network for the control group with no APOE ε4 allele. The upper right panel contains the network for the control group with at least one APOE ε4 allele. The lower left panel represents the network for the AD group with no APOE ε4 allele. The lower right panel represents the network for the AD group with at least one APOE ε4 allele. The metabolite compounds are colored according to the metabolite family: blue for amines, yellow for lipids, orange for organic acids, and purple for oxidative stress. Solid edges represent positive partial correlations, whereas dashed edges represent negative partial correlations. Abbreviations: AD, Alzheimer's disease; APOE, apolipoprotein E.