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. 2017 Sep 20;12(9):e0184593. doi: 10.1371/journal.pone.0184593

Fig 1. Copeptin and NSE concentrations in serum samples over time (n = 75).

Fig 1

(A, B) Copeptin levels decrease over time, with highest levels measured at 6 hours after birth. Copeptin concentrations are shown for individual neonates (A) as well as the median ±IQR concentration for each time point (B). Compared to the 6 hour time point, concentrations were significantly lower at all subsequent time points (p = 0.0448 at 6 vs. 12 hours, and p < 0.0001 at all other time points). (C, D) NSE levels are relatively stable until 24 h after birth, after which the levels decrease. Data is shown for individual neonates (C) and as the median ± IQR at each time point (D). Compared to the 6 hour time point, concentrations were significantly lower only at 168 hours after birth (p = 0.0013). The Kruskal-Wallis test with Dunn’s multiple comparisons test was used.