Fig 7. Model of membrane fluidity regulation by PAQR-2/AdipoR2.

This revised model proposes that PAQR-2 (AdipoR2 in mammals) and IGLR-2 (homolog unknown in human) act as sensors that are activated by low membrane fluidity caused by cold (in C. elegans) or exogenous SFAs (in C. elegans and human cells), and act on downstream effectors to restore fluidity by promoting changes in fatty acid metabolism, including promoting the activity of fatty acid desaturases. In this visualization, the red head groups indicate phospholipids with UFAs resulting from PAQR-2/AdipoR2 activity.