Table 3.
Additional parameters assessing the diagnostic value of the antibodies and their combination.
| anti-CarP | anti-CCP | RF | anti-CCP or RF | anti-CCP or RF or anti-CarP | |
|---|---|---|---|---|---|
| PPV | |||||
| all | 76.3 | 88.4 | 80.6 | 78.9 | 73.4 |
| anti-CCP− | 34.8 | na | 45.0 | 45.0a | 37.6 |
| anti-CCP− & RF− | 22.2 | na | na | na | 22.2a |
| NPV | |||||
| all | 60.1 | 72.8 | 72.2 | 76.5 | 76.3 |
| anti-CCP− | 74 | na | 76.5 | 76.5a | 76.3 |
| anti-CCP− & RF− | 76.3 | na | na | na | 76.3a |
| LR+ | |||||
| all | 3.2 | 7.5 | 4.2 | 3.7 | 2.7 |
| anti-CCP− | 1.4 | na | 2.2 | 2.2a | 1.6 |
| anti-CCP− & RF− | 0.9 | na | na | na | 0.9a |
| LR− | |||||
| all | 0.7 | 0.4 | 0.4 | 0.3 | 0.3 |
| anti-CCP− | 0.9 | na | 0.8 | 0.8a | 0.8 |
| anti-CCP− & RF− | 1.0 | na | na | na | 1.0a |
| AUC | |||||
| all | 0.65 | 0.79 | 0.76 | 0.77 | 0.74 |
| anti-CCP− | 0.53 | na | 0.58 | 0.58a | 0.57 |
| anti-CCP− & RF− | 0.49 | na | na | na | 0.49a |
All refers to all RA patients, the other rows refer to the indicated subset of RA patients. aValues already presented in the table to the right, but duplicated to facilitate comparison. PPV = positive predictive value, NPV = negative predictive value, LR + = likelihood ratio of a positive finding, LR− = likelihood ratio of a negative finding and AUC = area under the Receiver Operating Curve. na = not applicable.