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. 2017 Sep 20;7:11969. doi: 10.1038/s41598-017-10583-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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1D imino proton NMR spectrum of (a) free QDH1, (b) QDH1 bound with half the molar equivalent of Phen-DC₃, and (c) QDH1 bound with equimolar ratio of Phen-DC₃, and (d) chemical structure of Phen-DC₃, a quadruplex-binder. Unbound and bound G-quadruplex imino proton peaks are labelled with open circles and filled diamonds, respectively, whereas duplex imino proton peaks of free QDH1 are labelled with filled squares. Peaks labelled with asterisks originate from the ligand Phen-DC₃. Schematic structure of Phen-DC₃ (in yellow) binding to the G-tetrad is shown on the right.