Figure 7.

In silico modelling of lung epithelial cell hypo-responsiveness to re-stimulation. (A) Overall production of IL-8 ($IL{8}_{tot}^{prod}$) for different combined values of τ and $t_{1/2}^{IRAK1p}$ is shown. τ represents the interval between the two stimuli: IL-1β and flagellin. $t_{1/2}^{IRAK1p}$ denotes for the half-life of phosphorylated IRAK-1, and its wild type value is 5.6 min. (B) Temporal dynamics of IL-8 (IL8; solid lines) and total amounts of IRAK-1 (IRAK1 _tot; dashed lines) are presented for different combinations of τ and $t_{1/2}^{IRAK1p}$. The selected combinations of τ and $t_{1/2}^{IRAK1p}$ (H,V and D) are delineated by different types of lines in a.