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. 2017 Sep 20;7:11968. doi: 10.1038/s41598-017-12210-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROC curves for 1,5-anhydroglucitol (1,5-AG) ((a) in the total group; (b) in the total group with combined model; (c) in the non-FDR subgroup; (d) in the FDR subgroup) in the diagnosis of diabetes. For the combination of FPG with serum 1,5-AG, the sensitivity, specificity, and AUC were 82.5%, 83.5%, and 0.912, respectively. As for the combination of FPG and HbA_1c, the sensitivity, specificity, and AUC were 74.4%, 91.2%, and 0.911, respectively. There was no significant difference in the AUCs (P > 0.05). However, the specificity and sensitivity differed significantly from each other (all P < 0.001). Abbreviation: AUC: area under the curve; FDR: first degree relative with diabetes; FPG: fasting plasma glucose; HbA _1c: glycated hemoglobin A_1c; ROC: receiver operating characteristic.