FIG 3.

Survival of outbred CD1 mice after pulmonary challenge with hvKP1 (wild type) and hvKP1Δpeg-344. Strains were grown overnight in LB medium and diluted in 1× PBS, and animals underwent pulmonary challenge with the titers listed in each panel. An in extremis state or death was scored as nonsurvival for animals monitored for 14 days (n = 7 to 8 for each titer of each strain). The growth/survival of animals challenged with hvKP1Δpeg-344 was significantly decreased compared to that of animals challenged with hvKP1 at the titers listed in panel B (*, P < 0.05, as determined by a log rank [Mantel-Cox] test).