FIG 1.

Tpl2^−/− mice have a greater bacterial burden during peak infection. Wild-type (WT) and Tpl2^−/− mice were gavaged with 2 × 10⁹ CFU of Citrobacter rodentium (ICC180). Bioluminescent images from the gastrointestinal region are displayed as pseudocolor images, with variations in color representing the light intensity at a given location. Red represents the most intense light emission, while purple corresponds to the weakest signal. (A and B) Representative (A) and pooled (B) luminescence data for wild-type and Tpl2^−/− mice from 3 to 21 dpi are shown. (C) The fecal burden was quantified at 0 to 21 dpi. Dashed line, limit of detection. When no fecal burden was detected, a value of 3 × 10² CFU/g was assigned. Data from two independent experiments were pooled (n = 8 mice). Error bars represent SEMs. P values were determined by two-way ANOVA. *, P < 0.05; **, P < 0.005.