Table 1.

Study schedule presenting an overview of all study activities.

Study activities		0 w	Baseline	4 w	10 w	16 w	28 w	40 w	52 w	68 w
Before treatment
	Mapping and mammography	X
	Written informed consent	X
	Require histological samples (incl. mapping) and mammography results from referring hospital	X
Imiquimod 5% cream			Start			Stop
	Consultation by phone				X
	Consultation at outpatient clinic of involved research clinic, containing:		X	X		X	X	X	X	X
	Vulvar examination, measurement and photo documentation		X	X			X			X
	VAS score		X	X	X	X	X	X	X	X
	Tolerability questionnaire			X	X	X
	Biopsy	X		X			X
	EQ5D		X	X			X
	DLQI		X	X			X
	FSDS		X	X			X
	Review patient diary			X	X	X