Figure 3.

C05D10.2/swip-13 encodes an ortholog of mammalian ERK7/8. Sequence alignment of C05D10.2 with rat ERK7 and human ERK8 shows a high level of sequence identity, including the site of the vt32 mutation (red highlight), as well as the TEY phosphoactivation motif (yellow highlight) and the conserved Lys residue that can be mutated to Arg to abolish kinase activity (green highlight).Conservation between these proteins is highest in the putative kinase domain (Abe et al., 2002; blue box), and the majority of divergence appears to be in the long C-terminal tail.