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. 2017 Sep 20;18:180. doi: 10.1186/s13059-017-1310-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Model of multi-level tRNA gene regulation during macrophage development. a DNA loops bring together distal tRNA genes, RNAPII-transcribed genes, and enhancers that are coordinately downregulated during macrophage differentiation. b tDNAs are locally organized into clusters and physical contact domains that share similar activity and differential expression patterns in THP-1 cells. c Dynamic tDNA transcription correlates with proximal motif occupancy for specific, putative regulatory factors, such as HIF1A and EGR1. Downregulation of tRNA genes coincides with enhanced promoter-proximal binding of MAF1, a negative effector of RNAPIII activity