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Molecular formats of bispecific antibodies. According to the Fc domain, BsAbs can be divided into two types: IgG-format molecules and non-IgG-format molecules. IgG-like BsAbs mainly include quandroma, knobs-into-holes, scFv-IgG, (IgG)2, scFv-Fc, and nanobody. The Fc-free BsAbs contain tandscFv, DART, TandAb, F(ab’)2, diabody, ImmTAC, Dock and Lock, and scFv-HSA-scF
