TABLE II. Antimalarial activity of the compound epoxycytochalasin H isolated from the endophytic fungus Diaporthe miriciae UFMGCB 9720.
| Compound | Plasmodium falciparum | ||||
|---|---|---|---|---|---|
|
| |||||
| D6a - IC50 | D6a - SI | W2b - IC50 | W2b - SI | VEROc IC50 | |
| Epoxycytochalasin H | 51.70 | > 92.10 | 39.40 | > 120.70 | > 4760 |
| Chloroquined | 10.33 | >23 | 137.65 | > 1.70 | > 238 |
| Artemisinind | 2.87 | >83 | 3.21 | > 74 | > 238 |
a: Plasmodium falciparum chloroquine sensitive (D6); b: P. falciparum chloroquine resistant (W2); c: Cell VERO; d: control drug; IC50: inhibitory concentration of 50%; SI: selectivity index. Values calculated at ng mL-1.