Table 6.
Consistency of WM blood flow as measured by pCASL
| pCASL WM | V1 Mean [95% CIa] | V2 Mean [95% CIa] | V3 Mean [95% CIb] | MCV (%) [95% CI] | MRD (%) [95% CI] | ICC | Rating 3%c | Rating 10%c |
|---|---|---|---|---|---|---|---|---|
| Average |
7.39 [6.67, 8.12] |
7.49 [6.70, 8.28] |
7.32 [6.57, 8.08] |
4.7 [3.2, 6.1] |
6.3 [4.1, 8.1] |
0.982 |
N = 49 (Low) |
N = 6 (High) |
| Genu |
11.7 [10.5, 12.8] |
11.7 [10.5, 12.9] |
11.3 [9.98, 12.6] |
8.3 [6.3, 10.4] |
10.7 [8.2, 13.1] |
0.956 |
N = 136 (Low) |
N = 13 (High) |
| Body |
12.5 [11.3, 13.8] |
13.0 [11.6, 14.4] |
12.4 [10.9, 14.0] |
8.6 [7.0, 10.2] |
11.1 [9.1, 13.2] |
0.961 |
N = 159 (Low) |
N = 15 (High) |
| Splenium |
9.84 [8.83, 10.9] |
9.90 [8.71, 11.1] |
9.37 [8.07, 10.7] |
9.8 [7.3, 12.3] |
12.1 [9.3, 15.0] |
0.950 |
N = 200 (Low) |
N = 19 (High) |
| Fornix |
6.95 [5.84, 8.07] |
7.49 [6.51, 8.47] |
6.80 [5.91, 7.69] |
19.3 [14.1, 24.6] |
27.1 [18.5, 35.8] |
0.872 |
N = 757 (Low) |
N = 69 (Low) |
| Corticospinal |
3.38 [2.31, 4.46] |
3.74 [2.61, 4.87] |
3.19 [2.11, 4.27] |
47.4 [33.3, 61.5] |
76.3 [40.1, 112.6] |
0.900 |
N = 2690 (Low) |
N = 243 (Low) |
| Internal capsule |
10.9 [9.63, 12.1] |
11.3 [9.99, 12.7] |
10.5 [9.12, 12.0] |
11.4 [9.2, 13.6] |
15.3 [12.1, 18.6] |
0.946 |
N = 263 (Low) |
N = 25 (Moderate) |
| Corona radiata |
9.33 [8.23, 10.4] |
9.71 [8.53, 10.9] |
9.05 [7.87, 10.2] |
9.8 [7.8, 11.8] |
12.7 [10.1, 15.4] |
0.947 |
N = 219 (Low) |
N = 21 (Moderate) |
| Thalamic radiation |
9.16 [8.04, 10.3] |
9.49 [8.28, 10.7] |
8.91 [7.68, 10.1] |
10.6 [7.8, 13.3] |
13.5 [9.7, 17.3] |
0.949 |
N = 241 (Low) |
N = 23 (Moderate) |
| Sagittal striatum |
9.34 [8.28, 10.4] |
9.94 [8.73, 11.2] |
8.77 [7.73, 9.81] |
10.2 [7.4, 12.9] |
13.1 [9.7, 17.4] |
0.949 |
N = 229 (Low) |
N = 22 (Moderate) |
| External capsule |
11.9 [10.8, 13.0] |
12.5 [11.3, 13.7] |
11.4 [10.2, 12.7] |
10.4 [7.9, 13.0] |
13.4 [10.1, 16.7] |
0.926 |
N = 223 (Low) |
N = 21 (Moderate) |
| Cingulum |
17.1 [15.3, 19.0] |
17.4 [15.6, 19.3] |
16.5 [14.2, 18.7] |
10.0 [7.2, 12.7] |
13.3 [9.3, 17.4] |
0.953 |
N = 203 (Low) |
N = 19 (High) |
| Superior longitudinal fasciculus |
11.2 [9.93, 12.5] |
11.7 [10.3, 13.2] |
11.0 [9.49, 12.5] |
10.9 [8.1, 13.7] |
14.4 [10.2, 18.6] |
0.935 |
N = 249 (Low) |
N = 25 (Moderate) |
| Fronto‐occipital |
10.2 [8.82, 11.5] |
10.7 [9.30, 12.0] |
10.1 [8.78, 11.5] |
13.3 [10.5, 16.1] |
17.9 [13.1, 22.6] |
0.919 |
N = 382 (Low) |
N = 35 (Moderate) |
CI, confidence interval [lower limit, upper limit]; MCV, mean coefficient of variation; ICC, intraclass correlation; MRD, mean relative difference.
a
N = 25.
b
N = 22 (three subjects only completed two visits), mean values for three visits in units of ml/100 g/min.
c
Reproducibility rating for 10% detection, power = 0.9, and significance = 0.05.