Table 7.
Consistency of proton magnetic resonance spectroscopy
| Metabolite | V1 Mean [95% CIa] | V2 Mean [95% CIa] | V3 Mean [95% CIb] | MCV (%) [95% CI] | MRD (%) [95% CI] | ICC | Rating (3%)c | Rating (10%)c |
|---|---|---|---|---|---|---|---|---|
| TE135 frontal lobes WM | ||||||||
| Mean tCho |
1.91 [1.81, 2.01] |
1.86 [1.78, 1.94] |
1.89 [1.79, 1.99] |
3.9 [3.1, 4.7] |
5.0 [3.9, 6.0] |
0.962 |
N = 35 (Moderate) |
N = 4 (High) |
| Mean tNAA |
11.0 [10.6, 11.4] |
11.0 [10.7,11.4] |
10.9 [10.6, 11.3] |
2.8 [1.8, 3.9] |
3.7 [2.3, 5.1] |
0.914 |
N = 19 (High) |
N = 3 (High) |
| Mean tCr |
5.05 [4.89, 5.21] |
5.0 [4.80, 5.12] |
5.03 [4.87, 5.19] |
4.1 [3.1, 5.1] |
5.3 [4.0, 6.7] |
0.851 |
N = 38 (Moderate) |
N = 5 (High) |
| TE30 frontal lobes WM | ||||||||
| Frontal mean Glu |
8.16 [7.73, 8.60] |
7.74 [7.41, 8.08] |
7.91 [7.45, 8.36] |
7.8 [6.3, 9.3] |
10.1 [7.9, 12.2] |
0.816 |
N = 141 (Low) |
N = 14 (High) |
| Frontal mean tCho |
2.27 [2.14, 2.41] |
2.23 [2.13, 2.32] |
2.27 [2.12, 2.42] |
6.4 [4.6, 8.2] |
8.3 [5.8, 10.7] |
0.886 |
N = 91 (Low) |
N = 9 (High) |
| Frontal mean tNAA |
9.98 [9.62, 10.3] |
9.92 [9.61, 10.23] |
9.86 [9.51, 10.2] |
4.7 [2.9, 6.6] |
6.1 [3.7, 8.4] |
0.694 |
N = 51 (Low) |
N = 6 (High) |
| Frontal mean mI |
5.51 [5.24, 5.78] |
5.34 [5.02, 5.66] |
5.31 [4.99, 5.63] |
8.2 [6.2, 10.2] |
10.7 [8.1, 13.3] |
0.745 |
N = 155 (Low) |
N = 15 (High) |
| Frontal mean tCr |
7.32 [7.06, 7.57] |
7.01 [6.81, 7.22] |
7.02 [6.75, 7.30] |
6.1 [4.3, 7.9] |
7.7 [5.3, 10.1] |
0.565 |
N = 84 (Low) |
N = 9 (High) |
| Frontal mean Glu+Gln |
9.86 [9.30, 10.4] |
9.59 [9.22, 9.95] |
9.62 [9.10, 10.1] |
7.2 [5.7, 8.6] |
9.0 [7.0, 11.1] |
0.818 |
N = 119 (Low) |
N = 12 (High) |
| Frontal mean GSH |
2.44 [2.28, 2.59] |
2.36 [2.24, 2.49] |
2.31 [2.10, 2.51] |
11.3 [8.2, 14.5] |
14.1 [10.6, 17.6] |
0.696 |
N = 281 (Low) |
N = 26 (Moderate) |
| TE30 AC WM | ||||||||
| AC Glu |
13.3 [12.8, 13.7] |
13.4 [13.1,13.7] |
13.0 [12.6, 13.4] |
4.2 [3.3, 5.1] |
5.5 [4.2, 6.7] |
0.763 |
N = 43 (Low) |
N = 5 (High) |
| AC GSH |
2.43 [2.32, 2.55] |
2.46 [2.35, 2.58] |
2.42 [2.33, 2.52] |
6.1 [4.6, 7.6] |
7.8 [5.9, 9.8] |
0.798 |
N = 87 (Low) |
N = 9 (High) |
| AC tCho |
2.20 [2.08, 2.31] |
2.23 [2.14, 2.31] |
2.18 [2.07, 2.28] |
4.8 [3.5, 6.2] |
6.3 [4.4, 8.2] |
0.879 |
N = 52 (Low) |
N = 6 (High) |
| AC tNAA |
11.4 [11.1, 11.6] |
11.4 [11.2, 11.6] |
11.4 [11.2, 11.6] |
2.5 [1.8, 3.2] |
3.2 [2.3, 4.1] |
0.787 |
N = 15 (High) |
N = 3 (High) |
| AC mI |
6.65 [6.38, 6.91] |
6.75 [6.53, 6.98] |
6.62 [6.40, 6.85] |
4.3 [3.2, 5.4] |
5.6 [4.2, 6.9] |
0.781 |
N = 44 (Low) |
N = 6 (High) |
| AC tCr |
10.4 [10.2, 10.7] |
10.4 [10.2, 10.6] |
10.2 [10.0, 10.4] |
2.9 [2.2, 3.6] |
3.8 [2.8, 4.7] |
0.667 |
N = 21 (Moderate) |
N = 3 (High) |
| AC Glu+Gln |
15.1 [14.6, 15.6] |
15.2 [14.8, 15.5] |
15.0 [14.5, 15.5] |
4.6 [3.6, 5.5] |
5.9 [4.6, 7.2] |
0.765 |
N = 51 (Low) |
N = 4 (High) |
AC, anterior cingulate; MRD, mean relative difference; CI, confidence interval [lower limit, upper limit]; MCV, mean coefficient of variation; Glu, glutamate; Glu+Gln, glutamate+glutamine; GSH, glutathione; GM, gray matter; ICC, intraclass correlation; mI, myo‐Inositol; Cr, total creatine; tCho, choline; tNAA, total N ‐acetylaspartate; WM, white matter.
a
N = 25.
b
N = 22 (three subjects only completed two visits), mean metabolites are in institutional units.
c
Reproducibility rating for 10% detection, power = 0.9, and significance = 0.05.