Table 1.
Demographic and clinical information of included patients with mild traumatic brain injury
| Variable | Overall (N = 114) | APOE ε4(−) (N = 79) | APOE ε4(+) (N = 35) | Sig. (p) |
|---|---|---|---|---|
| Age (years) | ||||
| Mean ± SD | 42.8 ± 16.2 | 39.7 ± 16.5 | 49.6 ± 13.6 | .002 |
| Gender | ||||
| Male | 76 (67%) | 49 (62%) | 27 (77%) | .114 |
| Female | 38 (33%) | 30 (38%) | 8 (23%) | |
| Race | ||||
| Caucasian | 83 (73%) | 58 (70%) | 25 (30%) | .012 |
| African‐American/African | 16 (14%) | 7 (44%) | 9 (56%) | |
| Other races | 15 (13%) | 14 (93%) | 1 (7%) | |
| PMH Seizures | ||||
| No | 100 (88%) | 70 (89%) | 30 (86%) | .664 |
| Yes | 14 (12%) | 9 (11%) | 5 (14%) | |
| Education (years) | ||||
| Mean ± SD | 14.2 ± 2.9 | 14.3 ± 3.1 | 13.7 ± 2.1 | .280 |
| Mechanism of injury | ||||
| Motor vehicle accident | 24 (21%) | 17 (22%) | 7 (20%) | .910 |
| Cyclist/pedestrian hit | 16 (14%) | 11 (14%) | 5 (14%) | |
| Fall | 53 (47%) | 38 (48%) | 15 (43%) | |
| Assault | 16 (14%) | 10 (13%) | 6 (17%) | |
| Struck by/against object | 5 (4%) | 3 (4%) | 2 (6%) | |
| Loss of consciousness | ||||
| No | 26 (23%) | 19 (24%) | 7 (20%) | .634 |
| Yes/unknown | 88 (77%) | 60 (76%) | 28 (80%) | |
| Posttraumatic amnesia | ||||
| No | 46 (40%) | 30 (38%) | 16 (46%) | .437 |
| Yes/unknown | 68 (60%) | 49 (62%) | 19 (54%) | |
| ED arrival GCS | ||||
| 13–14 | 23 (20%) | 16 (20%) | 7 (20%) | .975 |
| 15 | 91 (80%) | 63 (80%) | 28 (80%) | |
| CT pathology | ||||
| Absent | 85 (75%) | 58 (73%) | 27 (77%) | .674 |
| Present | 29 (25%) | 21 (27%) | 8 (23%) | |
Race distributions are reported as row percentages. All other distributions reported as column percentages. The race subgroup “Other races” was combined due to individual small sample sizes of Asian [N = 6; ε4(−) = 5, ε4(+) = 1], American Indian/Alaskan Native [N = 1; ε4(−) = 1], Hawaiian/Pacific Islander [N = 2; ε4(−) = 2], and more than one race [N = 6; ε4(−) = 6]. ED Arrival GCS was combined due to N = 1 for GCS 13 in both APOE groups.
APOE, apolipoprotein E; CI, confidence interval; ED, emergency department; GCS, Glasgow Coma Scale; PMH, prior medical history; SD, standard deviation.