Fig. 4.

Relationships between measures of pathology or behaviour in male rTg4510 CC mice. Strong negative correlation was observed between measures of tau burden and atrophy in both the hippocampus and cortex (a). Open-field locomotor activity was correlated with all three other behavioural assays: T-maze rewarded alternation, Y-maze spatial novelty preference, and the acquisition of the aversive Y-maze spatial reference memory task (b). Small squares = 4 months; medium squares = 8 months; large squares = 12 months