Fig. 5.

Relationships between measures of pathology and behaviour in male rTg4510 CC mice. Locomotor activity and T-maze performance were strongly related to all pathological endpoints. Aversive Y-maze spatial learning also correlated with atrophy in both the hippocampus and cortex, which was not the case for Y-maze novelty preference. Small squares = 4 months; medium squares = 8 months; large squares = 12 months