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IC50 values against each drug of parental and docetaxel resistant cell lines.
| Cell Line | EGFR-mutation | Docetaxel (nM) | Gefitinib (µM) | Afatinib (µM) | AZD9291 (µM) |
|---|---|---|---|---|---|
| H1299 | Wild-type | 3.2 | >10 | 4.3 | 5.8 |
| H1299-DR | Wild-type | 272.1 | >10 | 5.7 | 5.5 |
| HCC827 | Exon 19 del (E746-A750) | 0.3 | 0.0005 | <0.001 | <0.001 |
| HCC827-DR | Exon 19 del (E746-A750) | >1000 | 5.0 | 1.6 | 2.5 |
| HCC4006 | Exon 19 del (L747–A750, P ins) | 0.02 | 0.031 | 0.002 | 0.025 |
| HCC4006-DR | Exon 19 del (L747–A750, P ins) | >1000 | 8.3 | 2.7 | 3.1 |
