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. 2017 Jul 27;14(4):3893–3898. doi: 10.3892/ol.2017.6685

Figure 1.

Figure 1.

Targets and functional consequences of Wip1 signaling. Wip1 directly dephosphorylates target proteins including ATM, Chk1/2, Mdm2/X, p53, p38 MAPK, p16, CXCR4 and AKT, resulting in inhibition of apoptosis and cell cycle arrest, which promotes tumorigenesis, invasion and migration. Wip1 leads to chemoresistance in tumor cell with wild-type p53. However, Wip1 increases chemosensitivity in p53-negative tumor cells by regulating Bax/Bcl-xl and RUNX-2. P38 MAPK, p38 mitogen activated protein kinases; Chk1/2, checkpoint kinase 1/2; Mdm2/X, murine double minute 2/X; CXCR4, C-X-C chemokine receptor type 4; AKT, protein kinase B; Bax, B-cell lymphoma-2 associated X protein; Bcl-xl, B-cell lymphoma-xl; RUNX-2, runt-related transcription factor-2; ATM, ataxia telangiectasia mutated; Wip1, wild-type p53-induced phosphatase 1.