Table 2.
Study patient characteristics
| All Patients | Pansclerotic | Generalized | P-value | |
|---|---|---|---|---|
| Total no. of patients | 113 | 13 | 100 | |
| Age, Yrs, mean (SD) | 53 (17) | 54 (21) | 53 (16) | 0.848 |
| Age Onset, Yrs, mean (SD) | 49 (19) | 53 (22) | 48 (18) | 0.447 |
| Time to Diagnosis, Mo, median (SD) | 9 (29) | 6 (13) | 10 (30) | 0.0332 |
| Gender, No. (%) | < 0.0001 | |||
| Male | 12 (10.6%) | 6 (46.2%) | 6 (6%) | |
| Female | 101 (89.4%) | 7 (53.8%) | 94 (94%) | |
| Race, n (%) | ||||
| Caucasian | 86 (76.1%) | 7 (53.8%) | 79 (79%) | 0.145 |
| Latino | 16 (14.2%) | 4 (30.8%) | 12 (12%) | 0.087 |
| African American | 6 (5.3%) | 2 (15.4%) | 4 (4%) | 0.141 |
| Asian | 3 (2.7%) | 0 (0%) | 3 (3%) | 1.000 |
| Other | 2 (1.8%) | 0 (0%) | 2 (2%) | 1.000 |
| Functional Impairment, No. (%) | 24 (21.2%) | 8 (61.5%) | 16 (16%) | 0.005 |
| Deep Involvement, No. (%) | 25 (22.1%) | 8 (61.5%) | 17 (17%) | 0.004 |
| No. of Treatments, No. (SD) | 2.4 (2) | 2.8 (2) | 2.3 (2) | 0.175 |
| MRSS, mean (SD) | 8 (6) | 18 (9) | 7 (4) | 0.002 |
| DLQI, mean (SD) | 7 (6) | 12 (8) | 6 (6) | 0.056 |
| LoSAI, mean (SD) | 31 (27) | 54 (40) | 27 (22) | 0.065 |
| LoSDI, mean (SD) | 24 (19) | 48 (26) | 20 (14) | 0.009 |
| PGA-A, mean (SD) | 54 (29) | 64 (30) | 53 (29) | 0.308 |
| PGA-D, mean (SD) | 31 (23) | 52 (34) | 27 (19) | 0.048 |
Abbreviations: Dermatology Life Quality Index (DLQI), Localized Scleroderma Skin Activity Index (LoSAI), Localized Scleroderma Skin Damage Index (LoSDI), Modified Rodnan Skin Score (mRSS), Physician Global Assessment of Disease Activity (PGA-A), Physician Global Assessment of Disease Activity (PGA-A), standard deviation (SD)