Fig. 1.
Brain-derived neurotrophic factor (BDNF) and 5-hydroxytryptamine 2A (5-HT2A) expression levels are modulated by apolipoprotein E (ApoE) in an isoform-dependent manner. Expression levels of (a) BDNF and tropomyosin receptor kinase B (TrkB) and (b) 5-HT1A and 5-HT2A were examined in the cortices of 6-month-old human ApoE2, ApoE3, and ApoE4 gene-targeted replacement female mice. The integrated density value of the bands in Western blots was determined using densitometry, and data were normalized to an internal loading control (β-tubulin) and to the ApoE2 group. Data are shown as mean ± SD (n = 5). *p < 0.05, **p < 0.01 by one-way analysis of variance with Tukey’s post hoc test