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. 2017 Sep 21;18:181. doi: 10.1186/s13059-017-1309-9

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Summary of the DESMAN pipeline. A full description of the statistics and bioinformatics underlying DESMAN is given in ‘Methods’. The software itself is available open source from https://github.com/chrisquince/ DESMAN. COG cluster of orthologous groups of proteins, SCSG single-copy core species gene Tetranucleotide Frequencies (TNF)