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. Author manuscript; available in PMC: 2017 Sep 21.
Published in final edited form as: Am J Transplant. 2015 Feb 3;15(7):1933–1947. doi: 10.1111/ajt.13185

Table 2. Shared biologic pathways enriched by differentially expressed miRNAs in DSA+BOS– patients and DSA+BOS+ patients.

Comparison DSA+BOS− versus Stable
KEGG pathway p-value, FDR corrected Selected miRNAs
TGF-beta signaling pathway 8.05E-28 miR-98, miR-125a-5p, miR-548c-5p, miR-133b, miR-134, miR-433,, miR-627, miR-874
MAPK signaling pathway 8.05E-28 miR-125a-5p, miR-137, miR-184, miR-203, miR-134, miR-433, miR-489, miR-494
PI3K-Akt signaling pathway 8.05E-28 let-7c, miR-299-5p, miR-338-3p, miR-381, miR-627, miR-874, miR-875-5p
Ubiquitin mediated proteolysis 2.46E-20 miR-125a-5p, miR-137, miR-203, miR-299-5p, miR-875-5p, miR-134, miR-433
Adherens junction 3.23E-19 miR-137, miR-203, miR-299-5p, miR-338-3p, miR-381, miR-875-5p
Focal adhesion 7.40E-18 miR-299-5p, miR-338-3p, miR-381, miR-627, miR-874, miR-134, miR-433, miR-489
Wnt signaling pathway 2.77E-15 let-7c, miR-98, miR-134, miR-433, miR-494, miR-503, miR-628-5p
mTOR signaling pathway 3.57E-10 let-7c, miR-299-5p, miR-338-3p, miR-381, miR-548c-5p, miR-874, miR-628-5p
B cell receptor signaling pathway 9.00E-10 miR-184, miR-203, miR-299-5p, miR-338-3p, miR-381, miR-134, miR-433, miR-628-5p
Regulation of actin cytoskeleton 1.49E-09 let-7c, miR-338-3p, miR-381, miR-548c-5p, miR-627, miR-874, miR-875-5p, miR-494
Toll-like receptor signaling pathway 1.52E-08 miR-125a-5p, miR-137, miR-627, miR-875-5p, miR-133b, miR-433, miR-489, miR-503
Jak-STAT signaling pathway 2.68E-08 let-7c, miR-98, miR-299-5p, miR-338-3p, miR-381, miR-548c-5p, miR-627
Hedgehog signaling pathway 5.39E-08 miR-338-3p, miR-381, miR-548c-5p, miR-875-5p, miR-503, miR-628-5p
Bacterial invasion of epithelial cells 1.19E-07 let-7c, miR-98, miR-338-3p, miR-381, miR-548c-5p, miR-627, miR-874, miR-503, miR-628-5p
Notch signaling pathway 6.70E-07 miR-137, miR-299-5p, miR-338-3p, miR-433, miR-489, miR-494, miR-628-5p
Regulation of autophagy 6.12E-06 miR-299-5p, miR-338-3p, miR-381, miR-548c-5p, miR-627, miR-133b, miR-494, miR-628-5p
Tight junction 1.35E-05 let-7c, miR-98, miR-299-5p, miR-338-3p, miR-133b, miR-134, miR-433, miR-503, miR-628-5p
T cell receptor signaling pathway 2.94E-05 miR-184, miR-299-5p, miR-338-3p, miR-134, miR-433, miR-489, miR-542-5p, miR-628-5p
Fc gamma R-mediated phagocytosis 4.00E-05 miR-203, miR-299-5p, miR-338-3p, miR-381, miR-503, miR-628-5p
Chemokine signaling pathway 4.00E-05 miR-98, miR-125a-5p, miR-627, miR-874, miR-875-5p, miR-489, miR-542-5p, miR-628-5p
Apoptosis 1.22E-04 let-7c, miR-98, miR-299-5p, miR-338-3p, miR-381, miR-542-5p, miR-628-5p
HIF-1 signaling pathway 2.28E-04 miR-125a-5p, miR-137, miR-548c-5p, miR-875-5p, miR-489, miR-494, miR-503, miR-628-5p
Cytokine-cytokine receptor interaction 7.50E-03 let-7c, miR-203, miR-299-5p, miR-627, miR-874, miR-134, miR-433, miR-494, miR-503
Comparison DSA+BOS+ versus Stable
KEGG pathway p-value, FDR corrected Differentially expressed miRNAs
TGF-beta signaling pathway 1.13E-20 miR-98, miR-125a-5p, miR-548c-5p, miR-548d-5p, miR-582-3p, miR-875-5p, miR-369-5p
MAPK signaling pathway 4.46E-31 miR-152, miR-193a-5p, miR-410, miR-422a, miR-450b-5p, miR-542-3p, miR-875-5p, miR-542-5p
PI3K-Akt signaling pathway 5.26E-40 miR-125a-5p, miR-329, miR-338-3p, miR-422a, miR-450b-5p, miR-582-3p, miR-627, miR-542-5p
Ubiquitin mediated proteolysis 7.00E-27 miR-193a-5p, miR-338-3p, miR-372, miR-381, miR-410, miR-450b-5p, miR-483-5p, miR-542-3p
Adherens junction 9.48E-17 let-7c, miR-1, miR-338-3p, miR-372, miR-548c-5p, miR-548d-5p, miR-582-3p, miR-511, miR-875-5p
Focal adhesion 4.44E-33 miR-137, miR-140-3p, miR-152, miR-381, miR-410, miR-548d-5p, miR-582-3p, miR-376c
Wnt signaling pathway 3.20E-15 miR-140-3p, miR-152, miR-193a-5p, miR-542-3p, miR-376c, miR-511, miR-941, miR-875-5p
mTOR signaling pathway 1.24E-09 miR-1, miR-98, miR-125a-5p, miR-137, miR-338-3p, miR-450b-5p, miR-542-3p, miR-511
B cell receptor signaling pathway 1.35E-03 let-7c, miR-329, miR-338-3p, miR-372, miR-381, miR-376c, miR-511, miR-134, miR-433, miR-628-5p
Regulation of actin cytoskeleton 6.10E-21 miR-98, miR-125a-5p, miR-137, miR-450b-5p, miR-483-5p, miR-627, miR-376c, miR-511, miR-875-5p
Toll-like receptor signaling pathway 3.58E-03 let-7c, miR-1, miR-98, miR-125a-5p, miR-193a-5p, miR-329, miR-338-3p, miR-875-5p, miR-542-5p
Jak-STAT signaling pathway 6.21E-14 miR-98, miR-203, miR-329, miR-338-3p, miR-422a, miR-450b-5p, miR-542-3p, miR-548d-5p, miR-582-3p
Hedgehog signaling pathway 1.93E-08 let-7c, miR-152, miR-203, miR-329, miR-338-3p, miR-450b-5p, miR-548c-5p, miR-548d-5p, miR-582-3p
Bacterial invasion of epithelial cells 2.81E-07 let-7c, miR-1, miR-140-3p, miR-152, miR-203, miR-422a, miR-548d-5p, miR-582-3p, miR-627, miR-875-5p
Notch signaling pathway 1.85E-09 let-7c, miR-125a-5p, miR-137, miR-338-3p, miR-381, miR-410, miR-582-3p, miR-511
Regulation of autophagy 3.88E-07 let-7c, miR-203, miR-338-3p, miR-372, miR-381, miR-548d-5p, miR-627, miR-376c, miR-511
Tight junction 9.11E-04 miR-125a-5p, miR-372, miR-381, miR-410, miR-548d-5p, miR-582-3p, miR-511, miR-875-5p
T cell receptor signaling pathway 8.70E-07 miR-98, miR-125a-5p, miR-137, miR-338-3p, miR-372, miR-381, miR-450b-5p, miR-941, miR-542-5p
Fc gamma R-mediated phagocytosis 4.92E-02 miR-137, miR-140-3p, miR-381, miR-410, miR-450b-5p, miR-671-3p, miR-376c, miR-511, miR-875-5p
Chemokine signaling pathway 4.29E-04 miR-125a-5p, miR-137, miR-140-3p, miR-548d-5p, miR-582-3p, miR-627, miR-219-1-3p, miR-542-5p
Apoptosis 4.98E-02 miR-140-3p, miR-152, miR-329, miR-422a, miR-450b-5p, miR-511, miR-941, miR-875-5p, miR-542-5p
HIF-1 signaling pathway 9.48E-17 miR-193a-5p, miR-203, miR-329, miR-542-3p, miR-548c-5p, miR-219-1-3p, miR-376c, miR-875-5p
Cytokine-cytokine receptor interaction 1.91E-03 miR-329, miR-338-3p, miR-542-3p, miR-219-1-3p, miR-376c, miR-511, miR-875-5p