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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Trends Genet. 2017 May 18;33(7):436–447. doi: 10.1016/j.tig.2017.04.005

Figure 1. A gene regulatory network.

Figure 1

A hypothetical GRN functioning in two cells is shown. Heavy lines indicate CRMs and lighter-weight lines TF-DNA or protein-protein interactions (→, transcriptional activation; —|, transcriptional repression; —o>—, ligand-receptor binding; —o)— signal transduction process; see [62]). The TF represented by light blue coloring at the upper left is a “master regulator” whose activity impinges on the expression of many other genes in the network, including its own via autoregulation. For an introduction to GRNs, see Levine and Davidson [63].