Table 3. Genotype frequencies and results of univariate Cox regression analysis of common polymorphisms and serous ovarian cancer survival with P < 0.2.
| Gene | Rs numbera | Genotype frequencies |
Trend test c |
Hazard ratio per-rare alleled |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA b | Aa | aa | Total | χ 2 | P-value | HR | LCL | UCL | ||
| MLH1 | rs1799977 | 206 | 160 | 48 | 414 | 5.71 | 0.02 | 1.3 | 1.05 | 1.6 |
| rs2286939 | 171 | 286 | 131 | 588 | 2.30 | 0.13 | 1.1 | 0.97 | 1.3 | |
| MSH6 | rs2348244 | 430 | 134 | 9 | 573 | 1.73 | 0.19 | 0.85 | 0.66 | 1.09 |
| MSH2 | rs2303428 | 485 | 97 | 6 | 588 | 2.24 | 0.13 | 1.2 | 0.95 | 1.6 |
| MSH3 | rs6151662 | 615 | 73 | 1 | 689 | 4.17 | 0.04 | 1.4 | 1.03 | 1.9 |
| PMS2 | rs2228006 | 515 | 163 | 11 | 689 | 3.14 | 0.08 | 0.83 | 0.66 | 1.03 |
| MLH3 | rs7303 | 153 | 273 | 147 | 573 | 3.01 | 0.08 | 0.87 | 0.74 | 1.02 |
| rs175080 | 185 | 274 | 118 | 577 | 1.77 | 0.18 | 1.1 | 0.95 | 1.3 | |
a
SNPs were genotyped in new batch of DNA samples containing 446 cases for MALOVA study, the rest of the SNPs in the table were genotyped in the subset of the MALOVA study (278 cases).
b
AA, common homozygote; Aa, heterozygote; aa, rare homozygotes.
c
Stratified by study.
d
Hazard ratio with 95% confidence interval.