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. Author manuscript; available in PMC: 2017 Sep 21.
Published in final edited form as: Toxicol In Vitro. 2016 Dec 7;39:104–110. doi: 10.1016/j.tiv.2016.12.004

Figure 2. Mechanisms of initial injury leading to basal cytotoxicity.

Figure 2

Chemicals can harm plasma membrane integrity through accumulation and binding to the phospholipid bilayer, called narcosis. Chemicals can negatively affect cellular energy supplies by targeting mitochondria. Chemicals can compromise subcellular architectural organization, called decompartmentalization.