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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Tetrahedron Lett. 2016 Dec 21;58(5):396–400. doi: 10.1016/j.tetlet.2016.12.018

Table 2.

Preparation of deuterodifluoromethyl ketones 27–35.

graphic file with name nihms840376t24.jpg
Entry Substrate Major Product Yielda % Db
1 4 graphic file with name nihms840376t25.jpg 89% 98%
2 5 graphic file with name nihms840376t26.jpg 86% 98%
3 6 graphic file with name nihms840376t27.jpg 47% 96%
4 7 graphic file with name nihms840376t28.jpg 89% 97%
5 8 graphic file with name nihms840376t29.jpg 90% 98%
6 9 graphic file with name nihms840376t30.jpg 26%c 99%
7 12 graphic file with name nihms840376t31.jpg 90% 99%
8 13 graphic file with name nihms840376t32.jpg 81% 99%
9 14 graphic file with name nihms840376t33.jpg 76% 98%

(d.r. = 4:3)
a

Isolated yields.

b

Percent deuterium incorporation were determined by 19F NMR, see Supporting Information for details.

c

The major product was the dimer and it was isolated in 69% yield, see Supporting Information for details.