Concept
|
Mean (n = 4)
|
S.D.
|
Comments
|
Initial 18F activity (mCi) |
148.0 |
44.9 |
Start of synthesis |
Precursor amount (μg) |
50 |
|
Use 50 μL of 1.0 mg/mL stock |
Activity left in QMA (mCi) |
3.0 |
1.7 |
Measured at the end of labeling step |
Radiolabeling yield |
29.7% |
6.3% |
Act_collection_vial ÷ (Act_collection_vial + Act_AluN) |
Radiochemical purity (HPLC-1) |
> 98% |
|
From HPLC-1 QC |
Spec. act. intermediate (mCi/μmol) |
122.9 |
29.7 |
From HPLC-1 using calibration curve |
Hydrogenation recovery (d.c.) |
74% |
9.0% |
Corrected for decay |
HPLC radiochemical purity (HPLC-2) |
90.7% |
2.9% |
Calculated from HPLC-2 |
Drying efficiency |
> 98% |
|
Corrected for decay |
Filtering recovery |
93.5% |
1.7% |
Corrected for decay |
Dose volume (mL) |
3.3 |
|
Collect fractions with highest radioactivity |
Spec. act. final product (mCi/µmol)
|
75.5
|
30.0
|
From HPLC-3 using calibration curve |
Synthesis efficiency
|
8.5%
|
3.6%
|
Non-decay corrected |
Synthesis time (min)
|
104
|
11.2
|
|