Table 4. Candidate genes for sex determination and differentiation in model organism.
Gene source | C.hongkongensis | T.granosa(homologues) | |
---|---|---|---|
WT1 | Mouse | ||
Sf1 | Mouse | ||
LHX9 | Mouse | Y | LHX9 |
EMX2 | Mouse | EMX1 | |
GATA4 | Mouse | Y | GATA4 |
SRY | Mouse | ||
Sox | Mouse | Y |
Sox2*(M), Sox8**(M), Sox9 Sox14**(M) |
RSP01 | Mouse | ||
FOG2 | Mouse | ||
AMH | Mouse | ||
DMRT | Mouse | DMRTA2 | |
MAP3K | Mouse | Y | MAP3K1, MAP3K4 |
ATRX | Mouse | Y | ATRX |
FGF9 | Mouse | FGF18 | |
Gadd45g | Mouse | Y | Gadd45g |
Hhat | Mouse | Y | |
Kdm3a | Mouse | ||
Dax1 | Mouse | Y | Dax1 |
Six | Mouse | Y | Six1, Six3, Six4 |
GSDF | Mouse | ||
PDGF | Mouse | ||
AR | Mouse | ||
SRD5A1 | Mouse | Y | |
WNT4 | Mouse | Y | Wnt4 |
FOXL2 | Mouse | Y | Foxl2**(F) |
β-catenin | Mouse | Y |
Armadillo/beta-catenin Armadillo/beta-catenin**(M) |
FST | Mouse | Y | FST-like |
cyp11b | Fish | ||
cyp19A1 | Fish | ||
ERa | Fish | Y | ERa |
Fhl2 | Fish | Fhl2 | |
Ixl | Fish | ||
Xol-1 | Worm | ||
Sdc | Worm | ||
Her | Worm | ||
Tra | Worm | Y | Tra-2 |
Fem | Worm | Y | Fem-1 |
CBX | Fly | CBX5, CBX8**(F) | |
Fru | Fly | ||
Sis | Fly | ||
Runt | Fly | Y | Runt |
Sxl | Fly | Sxl**(M) | |
Doa | Fly | Y | Doa |
Y represents the presence of these genes or their homologues in C. hongkongensis while the fourth column represents the homologues of these genes in T. granosa. M indicates significant expression in males while F indicates significant expression in females.
* indicates a significant difference (P<0.05) while
** indicates a highly significant difference (P<0.01).