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. 2017 Sep 21;12(9):e0184584. doi: 10.1371/journal.pone.0184584

Table 4. Candidate genes for sex determination and differentiation in model organism.

Gene source C.hongkongensis T.granosa(homologues)
WT1 Mouse
Sf1 Mouse
LHX9 Mouse Y LHX9
EMX2 Mouse EMX1
GATA4 Mouse Y GATA4
SRY Mouse
Sox Mouse Y Sox2*(M), Sox8**(M), Sox9
Sox14**(M)
RSP01 Mouse
FOG2 Mouse
AMH Mouse
DMRT Mouse DMRTA2
MAP3K Mouse Y MAP3K1, MAP3K4
ATRX Mouse Y ATRX
FGF9 Mouse FGF18
Gadd45g Mouse Y Gadd45g
Hhat Mouse Y
Kdm3a Mouse
Dax1 Mouse Y Dax1
Six Mouse Y Six1, Six3, Six4
GSDF Mouse
PDGF Mouse
AR Mouse
SRD5A1 Mouse Y
WNT4 Mouse Y Wnt4
FOXL2 Mouse Y Foxl2**(F)
β-catenin Mouse Y Armadillo/beta-catenin
Armadillo/beta-catenin**(M)
FST Mouse Y FST-like
cyp11b Fish
cyp19A1 Fish
ERa Fish Y ERa
Fhl2 Fish Fhl2
Ixl Fish
Xol-1 Worm
Sdc Worm
Her Worm
Tra Worm Y Tra-2
Fem Worm Y Fem-1
CBX Fly CBX5, CBX8**(F)
Fru Fly
Sis Fly
Runt Fly Y Runt
Sxl Fly Sxl**(M)
Doa Fly Y Doa

Y represents the presence of these genes or their homologues in C. hongkongensis while the fourth column represents the homologues of these genes in T. granosa. M indicates significant expression in males while F indicates significant expression in females.

* indicates a significant difference (P<0.05) while

** indicates a highly significant difference (P<0.01).