Fig 1. Pdgfra^Cre/ERT induced robust Cre-mediated recombination in Pdgfra-expressing tissues in mouse embryos.

We crossed the Pdgfra^Cre/ERT mice to Rosa26R (R26R) and tamoxifen (Tm) was administered at E9.5 by intragastic gavage. Embryos were collected at E11.5 and processed for whole mount X-gal staining. Sagittal sectioning of the X-gal stained double transgenic (A-C) and control (D) (Pdgfra^Cre/ERT or R26R) littermates were shown for comparison. Highlighted regions were magnified and shown as insets. Abbreviations: fv, forth ventricle; cm, cephalic mesenchyme; mnp, medial nasal process; max, maxillary process; man, mandibular process; h, heart; nt, neural tube.